spoVC [2019-07-19 10:41:42]

general stress protein, peptidyl-tRNA hydrolase

locus: BSU_00530

pI: 5.58

mw: 20.73 kDa

protein length: 188 aa

gene length: 567 bp

function: spore coat formation

product: peptidyl-tRNA hydrolase

essential: yes

ec: 3.1.1.29

synonyms: pth

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.12|Translation/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

Gene

Coordinates: 59,504 → 60,070

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• H₂O + N-acyl-L-α-aminoacyl-tRNA = an N-acyl-L-amino acid + H⁺ + tRNA (according to Swiss-Prot)

Protein family

• PTH family (single member, according to UniProt)

Structure

• [PDB|4QT4] (from ''Streptococcus pyogenes'', 48% identity) [Pubmed|25389518]

[SW|Localization]

• cytoplasm (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|40624E9FC30D75D172EF098C7FAC77B2573CC129|ctc]-[gene|FE7859E98F26E532AE02CD71B42B845BADBCF06E|spoVC]-[gene|C595D32D98723E93AF26B5C864FD61AF4739E069|fin]
  description: [pubmed|22383849]

  sigma factors

  • [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [pubmed|15805528], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]

  regulation

  • induced under stress conditions ([protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]) [pubmed|15805528]

References

• 11544224,12100553,25389518